Mechanism of COVID-19 adenovirus vaccines’ blood clotting adverse events unveiled by Canadian scientists
In their CITF-funded work, researchers from McMaster University, including Dr. Ishac Nazy, identified the mechanism behind adverse events involving blood clots associated with the COVID-19 adenovirus vaccines.
COVID-19 vaccination generates protective immune responses
Protection from COVID-19 vaccines is likely complex, requiring non-neutralizing antibodies, T cell responses, and innate immune mechanisms, as well as low levels of neutralizing antibodies.
International panel of experts states that allergic reactions to SARS-CoV-2 vaccines are very rare
An ad hoc panel of clinical experts from the US, Canada, UK, Ireland, Germany, Italy, South Africa, and Australia, including CITF Associate Scientific Director Dr. Bruce Mazer, was formed to synthesize the current evidence regarding severe allergic reactions to the SARS-CoV-2 vaccines, and provide consensus on recommendations regarding risk factors and management of patients at possible risk for severe allergic reactions.
SARS-CoV-2 infection in wild mice
SARS-CoV-2 was observed to infect many mammals, including deer mice, one of the most prevalent types of rodents in North America.
Interferons can fill the need for effective SARS-CoV-2 treatments, even in the COVID-19 vaccine era
People lacking certain immunity genes, particularly those involved in the can be more susceptible to infectious diseases. The link between this pathway and severe COVID-19 has already been established.
Early diagnosis and use of intravenous immunoglobulin can be helpful for managing SARS-CoV-2 vaccine-induced clotting-related adverse events
As more and more people become vaccinated against SARS-CoV-2 worldwide, a few cases of rare adverse events, clotting-related or immune thrombocytopenia, have been reported with the adenoviral-vector based Oxford-AstraZeneca ChAdOx1 nCoV-19 (AZ) or Johnson & Johnson/Janssen (J&J) vaccines.
Mental health matters: Study uncovers who is more at risk of mental health issues during the COVID-19 pandemic
The forced separation from family and friends and the disruption of regular activities brought on by the COVID-19 pandemic has had a tremendous effect on people’s well-being and mental health.
One dose of mRNA vaccine can protect the elderly against the Alpha and Gamma variants
Dr. Mel Krajden, COVID-19 Immunity Task Force (CITF) Leadership Group member and Vaccine Surveillance Reference Group (VSRG) member, and Dr. Danuta Skowronski, VSRG Effectiveness Working Party member, was part of a team evaluating the effectiveness of a single dose of a mRNA vaccine in people over 70.
A single dose of the Pfizer-BioNTech COVID-19 vaccine results in a robust response, especially in previously-infected individuals
Scientists from Université de Montréal, including Dr. Cecile Tremblay and CITF-funded researchers Drs. Daniel Kaufmann and Andrés Finzi, conducted a comprehensive study of the immune response against SARS-CoV-2, three weeks after a single dose of the Pfizer-BioNTech COVID-19 vaccine.