A high rate of successful intubation and a low risk of related adverse events were observed during the COVID-19 pandemic
A CITF-funded study, published in the Canadian Journal of Emergency Medicine, found that intubation was completed successfully on the first try in 94% of cases for both COVID-19 and non-COVID-19 patients presenting to the emergency department.
Canadian healthcare workers assisting COVID-19 patients had higher anxiety and depression scores than pre-pandemic
A CITF-funded study, published in the Journal of Occupational and Environmental Medicine, found that healthcare workers (HCWs) assisting patients with COVID-19 exhibited clinically significant scores for anxiety and depression and were more likely to report the use of sleep medications, compared to pre-pandemic.
Patients with NDD-CKD exhibit a strong humoral immune response after three COVID-19 mRNA vaccines
A CITF-funded proof-of-principle study, published in the Canadian Journal of Kidney Health and Disease, found that patients with non-dialysis-dependent chronic kidney disease (NDD-CKD)—a typically understudied population— had high seropositivity rates for anti-spike and anti-RBD after three doses of an mRNA COVID-29 vaccine.
Longer dose-intervals in COVID-19 vaccine series produced a more robust antibody response
A CITF-supported study, published in Frontiers in Immunology, found that delaying the second dose of an mRNA COVID-19 vaccine beyond approximately three months produced a more robust antibody response, despite this being a longer timeframe than was recommended by the vaccine manufacturers.
High avidity anti-N IgG antibodies detect SARS-CoV-2 reinfections with higher specificity compared to anti-N IgG serum levels alone
A CITF-funded proof-of-principle study, published in the Journal of Infectious Diseases, found that high avidity anti-nucleocapsid (anti-N) IgG antibodies detect SARS-CoV-2 reinfections with higher specificity compared to solely measuring anti-N IgG serum levels.
Understanding human rights legal considerations in vaccination mandates for businesses
A commentary by a CITF-funded researcher, published by the C.D. Howe Institute, discusses the differences in implementing vaccination mandates in businesses vs. in government sectors.
SARS-CoV-2 wastewater signal to clinical cases ratio could complement clinical case counts and wastewater signals as individual metrics
A CITF-funded study, published in Science of the Total Environment, demonstrated that the ratio of SARS-CoV-2 wastewater signals to clinical cases (WC ratio) would add more value to wastewater-based surveillance (WBS).
Optimization and validation of a cost-effective method for SARS-CoV-2 detection in wastewater
A CITF-funded study, published in Water, reported the development and optimization of a method for SARS-CoV-2 detection in wastewater using moderate-speed centrifuged solids. This method was then compared to an ultrafiltration reference method for detection rate, cost, simplicity, and turnaround times.
Frailty among long-term care residents did not impact SARS-CoV-2 antibody neutralization
A CITF-funded study, published in the Journal of the American Medical Directors Association, found that the frailty status of long-term care residents did not affect serum neutralizing antibodies against the either the ancestral or the Omicron strain of SARS-CoV-2.